Hypercholesterolemia and Coronary Risk in the Elderly: The Framingham Study.

Abstract

In a follow up of elderly Framingham men and women, and after multivariate adjustment, the total/high-density lipoprotein-cholesterol ratio remained highly associated with the incidence of coronary heart disease in both sexes, whereas total cholesterol level was associated with coronary heart disease only in women. Whereas total cholesterol values decline in the very elderly, and the association of coronary heart disease with total cholesterol level alone is weaker in the elderly than among those of middle age, the total/high-density lipoprotein-cholesterol ratio remains a strong predictor of coronary heart disease. In assessing the elderly for coronary risk, lipid measurements should include high-density lipoprotein-cholesterol and cholesterol determinations.

Keywords

MedicineFramingham Risk ScoreFramingham Heart StudyInternal medicineCholesterolCoronary heart diseaseCardiologyTotal cholesterolHigh-density lipoproteinIncidence (geometry)Risk factorDisease

Affiliated Institutions

Framingham Heart Study US

Related Publications

Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

Stanley S. Franklin , Shehzad Akbar Khan , Nathan D. Wong +2 more

Background —Current definitions of hypertension are based on levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP), but not on pulse pressure (PP). We exami...

1999 Circulation 1734 citations

Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome

Giulio Marchesini , Elisabetta Bugianesi , Gabriele Forlani +8 more

Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin–resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set. ...

2003 Hepatology 2654 citations

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?

Stanley S. Franklin , Martin G. Larson , Shehzad Akbar Khan +4 more

Background —We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age gr...

2001 Circulation 1366 citations

Effect of Antihypertensive Drug Treatment on Cardiovascular Outcomes in Women and Men

François Gueyffier

Background: Trials of drug therapy for hypertension have shown that such therapy has a clear overall benefit in preventing cardiovascular disease. Although these trials have inc...

1997 Annals of Internal Medicine 351 citations

Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease

Rory Collins , Stephen MacMahon

Most evidence about the effects of blood pressure on the risks of cardiovascular disease derives from two principal sources: prospective non-randomised observational studies of ...

1994 British Medical Bulletin 589 citations

Publication Info

Year: 1993
Type: article
Volume: 2
Issue: 2
Pages: 56-56
Citations: 28
Access: Closed

External Links

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                    Peter W.F. Wilson, 
                                
                                    William B. Kannel
                                
                            (1993). 
                            Hypercholesterolemia and Coronary Risk in the Elderly: The Framingham Study.. 
                            PubMed
                            , 2
                            (2)
                            , 56-56.