Abstract

Abstract A 51‐year‐old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft‐versus‐host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red‐rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine. Am. J. Hematol. 78:306–309, 2005. © 2005 Wiley‐Liss, Inc.

Keywords

MyopathyMedicineHydroxychloroquineMuscle biopsyPolyneuropathyGastroenterologyPathologyBiopsyInternal medicineDisease

MeSH Terms

BiopsyBone Marrow TransplantationChronic DiseaseEnzyme InhibitorsGraft vs Host DiseaseHumansHydroxychloroquineImmunosuppressive AgentsLymphomaMantle-CellMaleMiddle AgedMuscleSkeletalTreatment OutcomeVacuoles

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Publication Info

Year
2005
Type
article
Volume
78
Issue
4
Pages
306-309
Citations
43
Access
Closed

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Cite This

Javier Bolaños‐Meade, Lan Zhou, Ahmet Höke et al. (2005). Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft‐versus‐host disease. American Journal of Hematology , 78 (4) , 306-309. https://doi.org/10.1002/ajh.20294

Identifiers

DOI
10.1002/ajh.20294
PMID
15795921

Data Quality

Data completeness: 90%