Abstract
Uracil and thymme and their related nucleosides and nucleotides are degraded quantitatively by treatment with hydrazine hydrate at 90°. The reaction products are, respectively, pyrazol-3-one, and 5-methylpyrazol-3-one together with, in the case of the nucleosides and nucleotides, approximately quantitative yields of urea and a sugar or sugar phosphate hydrazone. Cytosine and its derivative are similarly degraded but two heterocyclic products, 3-aminopyrazole and NN′-di(3-pyrazolyl)hydrazine are obtained. Adenine and guanine, their related nucleosides, and guanine nucleotides are not degraded by hydrazine hydrate at 90° but adenine nucleotides are slowly attacked. In this reaction the only degradation product which has been identified is inorganic phosphate.
Keywords
NucleotideChemistryHydrazine (antidepressant)GuanineCytosineHydrateUracilHydrazoneSugar phosphatesPurine metabolismPhosphateOrganic chemistryBiochemistryDNAEnzyme
Related Publications
The Enzymology of Control by Feedback Inhibition
One way in which an organism controls its biosynthetic path- ways is by feedback inhibition. This control adjusts the rate of production of the end products of pathways, such as...
Publication Info
- Year
- 1967
- Type
- article
- Volume
- 16
- Pages
- 1528-1528
- Citations
- 25
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
25
OpenAlex
Cite This
D.H. Háyes,
F. Hayes-Baron
(1967).
Hydrazinolysis of some purines and pyrimidines and their related nucleosides and nucleotides.
Journal of the Chemical Society C Organic
, 16
, 1528-1528.
https://doi.org/10.1039/j39670001528
Identifiers
- DOI
- 10.1039/j39670001528