Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution

Abstract

To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

Keywords

BiologyGeneGeneticsLineage (genetic)GenomeChromosomeHuman genomeEvolutionary biologyConserved sequenceBreakpointComputational biologyPeptide sequence

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Publication Info

Year: 2001
Type: article
Volume: 293
Issue: 5527
Pages: 104-111
Citations: 216
Access: Closed

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APA Style

                            
                                
                                    Paramvir Dehal, 
                                
                                    Paul Predki, 
                                
                                    Anne S. Olsen
                                
                                et al.
                            
                            (2001). 
                            Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution. 
                            Science
                            , 293
                            (5527)
                            , 104-111.
                            https://doi.org/10.1126/science.1060310
                        

Identifiers

DOI: 10.1126/science.1060310