Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

Abstract

The nematode CED-4 protein and its human homolog Apaf-1 play a central role in apoptosis by functioning as direct activators of death-inducing caspases. A novel human CED-4/Apaf-1 family member called CARD4 was identified that has a domain structure strikingly similar to the cytoplasmic, receptor-like proteins that mediate disease resistance in plants. CARD4 interacted with the serine-threonine kinase RICK and potently induced NF-kappaB activity through TRAF-6 and NIK signaling molecules. In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappaB and apoptotic signaling pathways and may be a component of the host innate immune response.

Keywords

Family memberCell biologyProgrammed cell deathBcl-2 familyNFKB1ChemistryBiologyApoptosisGeneticsTranscription factorMedicineGene

Affiliated Institutions

Millennium Engineering and Integration (United States) US

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Publication Info

Year: 1999
Type: article
Volume: 274
Issue: 19
Pages: 12955-12958
Citations: 364
Access: Closed

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APA Style

                            
                                
                                    John Bertin, 
                                
                                    Waan-Jeng Nir, 
                                
                                    Colleen M. Fischer
                                
                                et al.
                            
                            (1999). 
                            Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB. 
                            Journal of Biological Chemistry
                            , 274
                            (19)
                            , 12955-12958.
                            https://doi.org/10.1074/jbc.274.19.12955
                        

Identifiers

DOI: 10.1074/jbc.274.19.12955