Abstract

The distribution of hematoporphyrin derivative has been studied in patients undergoing transurethral resections and total cystectomy for carcinoma of the bladder. Although hematoporphyrin derivative fluorescence was not confined to malignant tissues with the dose used there was preferential localization in malignant and pre-malignant epithelium. Also high intensity illumination of an area of hematoporphyrin derivative sensitized carcinoma caused tumor destruction. Therefore, it is suggested that hematoporphyrin derivative could be used as an aid to the diagnosis and treatment of carcinoma of the bladder.

Keywords

HematoporphyrinMedicinePhotodynamic therapyCarcinomaPathology

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Year
1976
Type
article
Volume
115
Issue
2
Pages
150-151
Citations
400
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John F. Kelly, M. E. SNELL (1976). Hematoporphyrin Derivative: A Possible Aid in the Diagnosis and Therapy of Carcinoma of the Bladder. The Journal of Urology , 115 (2) , 150-151. https://doi.org/10.1016/s0022-5347(17)59108-9

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DOI
10.1016/s0022-5347(17)59108-9