Abstract
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF and reduced EF, yet no effective treatment has been identified. While early research focused on the importance of diastolic dysfunction in the pathophysiology of HFpEF, recent studies have revealed that multiple non-diastolic abnormalities in cardiovascular function also contribute. Diagnosis of HFpEF is frequently challenging and relies upon careful clinical evaluation, echo-Doppler cardiography, and invasive haemodynamic assessment. In this review, the principal mechanisms, diagnostic approaches, and clinical trials are reviewed, along with a discussion of novel treatment strategies that are currently under investigation or hold promise for the future.
Keywords
MedicineHeart failure with preserved ejection fractionCardiologyHeart failureEjection fractionInternal medicineDiastolePathophysiologyDiastolic heart failureDiastolic functionHemodynamicsDoppler echocardiographyStroke volumeBlood pressure
MeSH Terms
AlgorithmsArrhythmiasCardiacBiomarkersCCN Intercellular Signaling ProteinsCardiotonic AgentsClinical Trials as TopicCollagenConnectinElasticityExerciseExercise TestExtracellular MatrixHeart FailureHumansHypertensionMatrix MetalloproteinasesMuscle ProteinsMyocytesCardiacPhysical ExertionProtein KinasesStroke VolumeTissue Inhibitor of MetalloproteinasesVascular DiseasesVascular StiffnessVentricular DysfunctionLeftVentricular Remodeling
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Publication Info
- Year
- 2010
- Type
- review
- Volume
- 32
- Issue
- 6
- Pages
- 670-679
- Citations
- 1054
- Access
- Closed
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Cite This
Barry A. Borlaug,
Walter J. Paulus
(2010).
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment.
European Heart Journal
, 32
(6)
, 670-679.
https://doi.org/10.1093/eurheartj/ehq426
Identifiers
- DOI
- 10.1093/eurheartj/ehq426
- PMID
- 21138935
- PMCID
- PMC3056204