Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Abstract

Microbial modulation of diabetes Short-chain fatty acids (SCFAs) are produced by various human gut microbes. SCFAs act as an energy source to the colonic epithelium and are also sensed by host signaling pathways that modulate appetite and inflammation. Deficiency of gut SCFAs is associated with type 2 diabetes. Zhao et al. found that adopting a high-fiber diet promoted the growth of SCFA-producing organisms in diabetic humans. The high-fiber diet induced changes in the entire gut microbe community and correlated with elevated levels of glucagon-like peptide-1, a decline in acetylated hemoglobin levels, and improved blood-glucose regulation. Science , this issue p. 1151

Keywords

Type 2 diabetesPrebioticFermentationGut floraFood scienceButyrateBacteroidesHemoglobinType 2 Diabetes MellitusFecesBiologyBacteriaBiochemistryDiabetes mellitusMicrobiologyEndocrinology

MeSH Terms

AdultAgedBacteriaChinaDiabetes MellitusType 2DietDietary FiberFatty AcidsVolatileFecesFemaleFermentationGastrointestinal MicrobiomeGlucagon-Like Peptide 1Glycated HemoglobinHumansHydrogen SulfideIndolesMaleMetagenomicsMiddle Aged

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Publication Info

Year: 2018
Type: article
Volume: 359
Issue: 6380
Pages: 1151-1156
Citations: 2114
Access: Closed

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APA Style

                            
                                
                                    Liping Zhao, 
                                
                                    Feng Zhang, 
                                
                                    Xiaoying Ding
                                
                                et al.
                            
                            (2018). 
                            Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. 
                            Science
                            , 359
                            (6380)
                            , 1151-1156.
                            https://doi.org/10.1126/science.aao5774
                        

Identifiers

DOI: 10.1126/science.aao5774
PMID: 29590046

Data Quality

Data completeness: 90%