Abstract

Nuclear genes control plastid differentiation in response to developmental signals, environmental signals, and retrograde signals from plastids themselves. In return, plastids emit signals that are essential for proper expression of many nuclear photosynthetic genes. Accumulation of magnesium-protoporphyrin IX (Mg-Proto), an intermediate in chlorophyll biosynthesis, is a plastid signal that represses nuclear transcription through a signaling pathway that, in Arabidopsis , requires the GUN4 gene. GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking.

Keywords

PlastidRetrograde signalingNuclear geneCell biologyBiologyArabidopsisSignal transductionGeneChloroplastIntracellularTranscription (linguistics)RegulatorBiochemistryGenome

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Publication Info

Year
2003
Type
article
Volume
299
Issue
5608
Pages
902-906
Citations
511
Access
Closed

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Cite This

Robert M. Larkin, José M. Alonso, Joseph R. Ecker et al. (2003). GUN4, a Regulator of Chlorophyll Synthesis and Intracellular Signaling. Science , 299 (5608) , 902-906. https://doi.org/10.1126/science.1079978

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DOI
10.1126/science.1079978