GRANULATION TISSUE AS A CONTRACTILE ORGAN

Abstract

Contracting granulation tissues contain fibroblasts that develop characteristics typical of smooth muscle: (a) They contain an extensive cytoplasmic fibrillar system. (b) They show immunofluorescent labeling of their cytoplasm with human anti-smooth muscle serum. (c) The nuclei show complicated folds and indentations, indicative of cellular contraction. (d) There are cell-to-cell and cell-to-stroma attachments. (e) It is possible to extract similar quantities of actomyosin (having the same adenosine triphosphatase activity) from granulation tissue and from pregnant rat uterus. (f) Strips of granulation tissue, when tested pharmacologically in vitro, behave similarly to smooth muscle. All these data support the view that, under certain conditions, fibroblasts can differentiate into a cell type structurally and functionally similar to smooth muscle and that this cell, the "myo-fibroblast," plays an important role in connective tissue contraction.

Keywords

Connective tissueGranulation tissueCytoplasmFibroblastCell biologyContraction (grammar)CellBiologyCell typeSmooth muscle tissueInterstitial cellSmooth muscleIn vitroAnatomyBiochemistryEndocrinologyImmunologyWound healing

MeSH Terms

ActomyosinAdenosine TriphosphatasesAnimalsAutonomic AgentsCell DifferentiationDesmosomesEndoplasmic ReticulumFibroblastsFluorescent Antibody TechniqueGranulation TissueInclusion BodiesMaleMicroscopyElectronMitochondriaMuscle ContractionMuscleSmoothMyofibrilsRatsWound Healing

Affiliated Institutions

University of Geneva CH

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Publication Info

Year: 1972
Type: article
Volume: 135
Issue: 4
Pages: 719-734
Citations: 805
Access: Closed

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APA Style

                            
                                
                                    Giulio Gabbiani, 
                                
                                    Bernard Hirschel, 
                                
                                    G.B. Ryan
                                
                                et al.
                            
                            (1972). 
                            GRANULATION TISSUE AS A CONTRACTILE ORGAN. 
                            The Journal of Experimental Medicine
                            , 135
                            (4)
                            , 719-734.
                            https://doi.org/10.1084/jem.135.4.719
                        

Identifiers

DOI: 10.1084/jem.135.4.719
PMID: 4336123
PMCID: PMC2139162

Data Quality

Data completeness: 86%