gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

Keywords

STAT3Cancer researchCarcinogenesisColitisInflammationTumor progressionBiologyCell growthTumor promotionCell cycleImmunologyCellSignal transductionCell biologyCancer

Affiliated Institutions

Related Publications

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

Bharat B. Aggarwal , R. V. Vijayalekshmi , Bokyung Sung

Abstract Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diet have been recognized as major risk factors for the most common...

2009 Clinical Cancer Research 765 citations

Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Daniel C. Gray , Adrian M. Jubb , Deborah Hogue +9 more

Abstract To identify genes that could serve as targets for novel cancer therapeutics, we used a bioinformatic analysis of microarray data comparing gene expression between norma...

2005 Cancer Research 200 citations

<b>A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode</b> .

Kristen L Murphy , Andrew P. Dennis , Jeffrey M. Rosen

ABSTRACT Approximately 40% of human breast cancers contain alterations in the tumor suppressor p53. The p53 172R‐H gain‐of‐function mutant (equivalent to the common 175R‐H human...

2000 The FASEB Journal 93 citations

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

Ian Sabroe , Lynne R. Prince , Elizabeth C. Jones +5 more

Abstract Neutrophil responses to commercial LPS, a dual Toll-like receptor (TLR)2 and TLR4 activator, are regulated by TLR expression, but are amplified by contaminating monocyt...

2003 The Journal of Immunology 339 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Philippe Delerive , Karolien De Bosscher , Sandrine Besnard +7 more

Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome pr...

1999 Journal of Biological Chemistry 1062 citations

Publication Info

Year: 2009
Type: article
Volume: 15
Issue: 2
Pages: 91-102
Citations: 925
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

925

OpenAlex

Cite This

APA Style

                            
                                
                                    Julia Bollrath, 
                                
                                    Toby J. Phesse, 
                                
                                    Vivian A. von Burstin
                                
                                et al.
                            
                            (2009). 
                            gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis. 
                            Cancer Cell
                            , 15
                            (2)
                            , 91-102.
                            https://doi.org/10.1016/j.ccr.2009.01.002
                        

Identifiers

DOI: 10.1016/j.ccr.2009.01.002