Global Assessment of Health Utilities Associated with Pneumococcal Disease in Adults: Targeted Literature Reviews

Abstract

This review identified substantial QoL burden associated with pneumococcal disease and PMS in adults; however, considerable variability in utility estimates exists. Utility inputs in CUAs of pneumococcal vaccines in adults often rely upon assumptions, pediatric studies, or utilities from other diseases, and there is relatively little data on the health utilities of IPD and neurological deficits in adults. Given the importance of health utilities in economic evaluations, CUAs should carefully select utility values by considering methodological robustness, the representativeness of health states, and the time frame over which health utilities are assessed and evaluate alternative sources and assumptions in sensitivity analyses.

Affiliated Institutions

• Merck & Co., Inc., Rahway, NJ, USA (United States) US
• Analysis Group (United States) US
• Duke University US
• University of Sheffield GB

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