Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Lecia V. Sequist , Belinda A. Waltman , Dora Dias‐Santagata , Lecia V. Sequist , Belinda A. Waltman , Dora Dias‐Santagata , Subba R. Digumarthy , Alexa B. Turke , Panos Fidias , Kristin Bergethon , Alice T. Shaw , Scott Gettinger , Arjola K. Cosper , Sara Akhavanfard , Rebecca S. Heist , Jennifer S. Temel , James G. Christensen , John C. Wain , Thomas J. Lynch , Kathy Vernovsky , Eugene J. Mark , Michael Lanuti , A. John Iafrate , Mari Mino‐Kenudson , Jeffrey A. Engelman
2011 Science Translational Medicine 3,483 citations

Abstract

Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.

Keywords

T790MEpidermal growth factor receptorCancer researchLung cancerEGFR inhibitorsDrug resistanceMutationMedicineBiologyGenotypeLungTyrosine kinaseResistance mutationGefitinibGenePathologyCancerInternal medicineReceptorPolymerase chain reactionGeneticsReverse transcriptase

Affiliated Institutions

Related Publications

Publication Info

Year
2011
Type
article
Volume
3
Issue
75
Pages
75ra26-75ra26
Citations
3483
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3483
OpenAlex

Cite This

Lecia V. Sequist, Belinda A. Waltman, Dora Dias‐Santagata et al. (2011). Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors. Science Translational Medicine , 3 (75) , 75ra26-75ra26. https://doi.org/10.1126/scitranslmed.3002003

Identifiers

DOI
10.1126/scitranslmed.3002003