Abstract

A single electrophoretic type (ET15) of Neisseria meningitidis has been associated with an increased incidence of group C meningococcal disease in Canada. Genomic fingerprinting through pulsed-field gel electrophoresis of chromosomal DNA was used to characterize the clonal relationship among meningococcal isolates of different electrophoretic types and among isolates within ET15. The genomic fingerprints of the ET15 isolates, while similar as a group, were sufficiently distinct to confirm linkage for four pairs of strains from focal outbreaks and differed markedly from those of the other common electrophoretic types, ET5, ET9, and ET21.

Keywords

Neisseria meningitidisMeningococcal diseaseBiologyNeisseriaceaeGeneticsDNA profilingMicrobiologyPulsed-field gel electrophoresisgenomic DNANeisseriaOutbreakGenotypeVirologyDNABacteriaGene

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Publication Info

Year
1993
Type
article
Volume
31
Issue
9
Pages
2506-2508
Citations
35
Access
Closed

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Craig A. Strathdee, Shaun Tyler, J. A. Ryan et al. (1993). Genomic fingerprinting of Neisseria meningitidis associated with group C meningococcal disease in Canada. Journal of Clinical Microbiology , 31 (9) , 2506-2508. https://doi.org/10.1128/jcm.31.9.2506-2508.1993

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DOI
10.1128/jcm.31.9.2506-2508.1993