Abstract
Several recent papers have used summary results from genome-wide association studies to characterize genetic overlap between human complex traits and common diseases.The emerging evidence is that individual DNA variants frequently influence multiple phenotypes, often in unexpected ways.This has important implications for genomic medicine and for the application of genome editing.
Keywords
PleiotropyHuman geneticsGenomic medicineComputational biologyPrecision medicineBiologyGeneticsSystems biologyGenomicsPersonalized medicineEvolutionary biologyBioinformaticsMedicinePhenotypeGenomeGene
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Publication Info
- Year
- 2016
- Type
- article
- Volume
- 8
- Issue
- 1
- Pages
- 78-78
- Citations
- 193
- Access
- Closed
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Cite This
Jacob Gratten,
Peter M. Visscher
(2016).
Genetic pleiotropy in complex traits and diseases: implications for genomic medicine.
Genome Medicine
, 8
(1)
, 78-78.
https://doi.org/10.1186/s13073-016-0332-x
Identifiers
- DOI
- 10.1186/s13073-016-0332-x