Genetic linkage between hereditary hemochromatosis and HLA.

Abstract

A large Mormon pedigree of a proband with hemochromatosis was studied, using transferrin saturation as the quantitative phenotypic trait. The analysis indicated that the inheritance of hemochromatosis was recessive, with partial expression in some heterozygotes. The lod score of 6.88 (theta = .0) was strongly indicative of linkage between the hemochromatosis locus and the human major histocompatibility (HLA) loci.

Keywords

HemochromatosisProbandGeneticsLocus (genetics)Hereditary hemochromatosisHuman leukocyte antigenHeterozygote advantageGenetic linkageBiologyTransferrin saturationPhenotypeAlleleGeneMutationAntigen

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Publication Info

Year: 1979
Type: article
Volume: 31
Issue: 5
Pages: 601-19
Citations: 105
Access: Closed

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APA Style

                            
                                    K Kravitz, 
                                
                                    Mark H. Skolnick, 
                                
                                    C. Cannings
                                
                                et al.
                            
                            (1979). 
                            Genetic linkage between hereditary hemochromatosis and HLA.. 
                            PubMed
                            , 31
                            (5)
                            , 601-19.