Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

Abstract

Abstract Splenic B cells from C57BL/10ScCr mice fail to respond to the mitogenic principle of lipopolysaccharide (LPS), and do not express a serologically defined “LPS receptor”. In contrast, polyclonal B cell responses to both purified protein derivative of tuberculin and lipoprotein are conserved.

Keywords

LipopolysaccharideBiologyPolyclonal antibodiesB cellImmunologyLipid ATuberculinReceptorMitogen-activated protein kinaseMolecular biologyAntibodyCell biologySignal transductionGeneticsTuberculosisMedicinePathology

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Publication Info

Year: 1977
Type: article
Volume: 7
Issue: 5
Pages: 325-328
Citations: 171
Access: Closed

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APA Style

                            
                                
                                    António Coutinho, 
                                
                                    Luciana Forni, 
                                
                                    Fritz Melchers
                                
                                et al.
                            
                            (1977). 
                            Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. 
                            European Journal of Immunology
                            , 7
                            (5)
                            , 325-328.
                            https://doi.org/10.1002/eji.1830070517
                        

Identifiers

DOI: 10.1002/eji.1830070517