Keywords
BiologyEpigeneticsTumor microenvironmentTumor progressionPhenotypeDNA methylationSomatic cellCarcinogenesisCellCancer researchCell biologyGeneticsCancerGeneTumor cellsGene expression
Affiliated Institutions
Related Publications
Prospective identification of tumorigenic breast cancer cells
Breast cancer is the most common malignancy in United States women, accounting for >40,000 deaths each year. These breast tumors are comprised of phenotypically diverse popul...
Modulation of several waves of gene expression during FGF‐1 induced epithelial‐mesenchymal transition of carcinoma cells
Abstract During epithelial‐mesenchymal transition (EMT), epithelial cells are converted into isolated motile and invasive mesenchymal cells. In model systems, EMT is induced mos...
Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor c...
Hallmarks of Cancer: New Dimensions
Abstract The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying...
PurityEst: estimating purity of human tumor samples using next-generation sequencing data
Abstract Summary: We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutat...
Publication Info
- Year
- 1984
- Type
- review
- Volume
- 3
- Issue
- 1
- Pages
- 25-42
- Citations
- 180
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
180
OpenAlex
Cite This
Garth L. Nicolson
(1984).
Generation of phenotypic diversity and progression in metastatic tumor cells.
Cancer and Metastasis Reviews
, 3
(1)
, 25-42.
https://doi.org/10.1007/bf00047691
Identifiers
- DOI
- 10.1007/bf00047691