Generalizability of Clinical Trial Results for Major Depression to Community Samples

Carlos Blanco; Mark Olfson; Renée D. Goodwin; Elizabeth L. Ogburn; Michael R. Liebowitz; Edward V. Nunes; Deborah S. Hasin

doi:10.4088/jcp.v69n0810

Abstract

The design of traditional clinical trials tends to exclude a majority of individuals with MDE. Selection of exclusion criteria may have a powerful influence on the generalizability of study results. Clinical trials should explain the rationale for their exclusion criteria and estimate the impact of eligibility criteria on the generalizability of trial results.

Keywords

Generalizability theoryMajor depressive episodeDepression (economics)PsychiatryPsychological interventionClinical trialMajor depressive disorderComorbidityMedicineMental healthPsychologyClinical psychologyInternal medicineCognition

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Publication Info

Year: 2008
Type: article
Volume: 69
Issue: 8
Pages: 1276-1280
Citations: 78
Access: Closed

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APA Style

                            
                                
                                    Carlos Blanco, 
                                
                                    Mark Olfson, 
                                
                                    Renée D. Goodwin
                                
                                et al.
                            
                            (2008). 
                            Generalizability of Clinical Trial Results for Major Depression to Community Samples. 
                            The Journal of Clinical Psychiatry
                            , 69
                            (8)
                            , 1276-1280.
                            https://doi.org/10.4088/jcp.v69n0810
                        

Identifiers

DOI: 10.4088/jcp.v69n0810