Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

Toshiya Inaba; William Roberts; Linda H. Shapiro; Kent W. Jolly; Susana C. Raimondi; Stephen D. Smith; A. Thomas Look

doi:10.1126/science.1386162

Abstract

A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene ( HLF ) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.

Keywords

Leucine zipperATF3BiologyTransactivationTranscription factorGeneFusion proteinMolecular biologySOX4Fusion geneChromosomal translocationZipperGene expressionGeneticsPromoter

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Publication Info

Year: 1992
Type: article
Volume: 257
Issue: 5069
Pages: 531-534
Citations: 295
Access: Closed

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APA Style

                            
                                
                                    Toshiya Inaba, 
                                
                                    William Roberts, 
                                
                                    Linda H. Shapiro
                                
                                et al.
                            
                            (1992). 
                            Fusion of the Leucine Zipper Gene <i>HLF</i> to the <i>E2A</i> Gene in Human Acute B-Lineage Leukemia. 
                            Science
                            , 257
                            (5069)
                            , 531-534.
                            https://doi.org/10.1126/science.1386162
                        

Identifiers

DOI: 10.1126/science.1386162