Abstract

Abstract An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation ( P < 10 −3 ) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

Keywords

Human brainResting state fMRINeuroscienceCorrelationCortex (anatomy)Nuclear magnetic resonanceMotor cortexEcho (communications protocol)Blood oxygenationIntensity (physics)Echo-planar imagingFunctional magnetic resonance imagingPhysicsMagnetic resonance imagingPsychologyMedicineComputer scienceMathematics

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Publication Info

Year
1995
Type
article
Volume
34
Issue
4
Pages
537-541
Citations
9850
Access
Closed

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Bharat B. Biswal, F. Zerrin Yetkin, Victor M. Haughton et al. (1995). Functional connectivity in the motor cortex of resting human brain using echo‐planar mri. Magnetic Resonance in Medicine , 34 (4) , 537-541. https://doi.org/10.1002/mrm.1910340409

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DOI
10.1002/mrm.1910340409