Abstract

Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in part, through the direct suppression of peroxisome proliferator–activated receptor γ. GATA-3–deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition.

Keywords

AdipocyteAdipogenesisTranscription factorBiologyCell biologyCellular differentiationEmbryonic stem cellFunction (biology)GeneEndocrinologyAdipose tissueGenetics

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Year
2000
Type
article
Volume
290
Issue
5489
Pages
134-138
Citations
533
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Closed

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Cite This

Qiang Tong, Gökhan Dalgin, Haiyan Xu et al. (2000). Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition. Science , 290 (5489) , 134-138. https://doi.org/10.1126/science.290.5489.134

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DOI
10.1126/science.290.5489.134