Abstract
The realization that cancer progression required the participation of cellular genes provided one of several key rationales, in 1986, for embarking on the human genome project. Only with a reference genome sequence could the full spectrum of somatic changes leading to cancer be understood. Since its completion in 2003, the human reference genome sequence has fulfilled its promise as a foundational tool to illuminate the pathogenesis of cancer. Herein, we review the key historical milestones in cancer genomics since the completion of the genome, and some of the novel discoveries that are shaping our current understanding of cancer.
Keywords
BiologyGenomeHuman genomeCancer genome sequencingGenomicsCancerComputational biologyGenome projectGeneticsPersonal genomicsComparative genomicsGene
Affiliated Institutions
Related Publications
An integrated encyclopedia of DNA elements in the human genome
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) pro...
HGVS Recommendations for the Description of Sequence Variants: 2016 Update
The consistent and unambiguous description of sequence variants is essential to report and exchange information on the analysis of a genome. In particular, DNA diagnostics criti...
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCO...
CADD: predicting the deleteriousness of variants throughout the human genome
Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particula...
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which pred...
Publication Info
- Year
- 2013
- Type
- review
- Volume
- 23
- Issue
- 7
- Pages
- 1054-1062
- Citations
- 174
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
174
OpenAlex
Cite This
David A. Wheeler,
Linghua Wang
(2013).
From human genome to cancer genome: The first decade.
Genome Research
, 23
(7)
, 1054-1062.
https://doi.org/10.1101/gr.157602.113
Identifiers
- DOI
- 10.1101/gr.157602.113