Abstract

A fundamental problem in chemistry and biochemistry is understanding the role of solvation in determining molecular properties. Recent advances in statistical mechanical theory and molecular dynamics methodology can be used to solve this problem with the aid of supercomputers. By using these advances the free energies of solvation of all the chemical classes of amino acid side chains, four nucleic acid bases and other organic molecules can be calculated. The effect of a site-specific mutation on the stability of trypsin is predicted. The results are in good agreement with available experiments.

Keywords

SolvationMolecular dynamicsNucleic acidComputational chemistryImplicit solvationMoleculeChemistryStatistical physicsStability (learning theory)Computer scienceBiological systemPhysicsOrganic chemistryBiochemistryMachine learningBiology

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Publication Info

Year
1987
Type
article
Volume
236
Issue
4801
Pages
564-568
Citations
412
Access
Closed

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Paul A. Bash, U. Chandra Singh, Robert Langridge et al. (1987). Free Energy Calculations by Computer Simulation. Science , 236 (4801) , 564-568. https://doi.org/10.1126/science.3576184

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DOI
10.1126/science.3576184