Filovirus‐Like Particles Produced in Insect Cells: Immunogenicity and Protection in Rodents

Kelly L. Warfield; Nichole A. Posten; Dana L. Swenson; Gene G. Olinger; Dominic Esposito; William Gillette; Ralph F. Hopkins; Julie Costantino; Rekha G. Panchal; James L. Hartley; M. Javad Aman; Sina Bavari

doi:10.1086/520612

Abstract

Together, these data suggest that filovirus-like particles produced by baculovirus expression systems, which are amenable to large-scale production, are highly immunogenic and are suitable as safe and effective vaccines for the prevention of filoviral infection.

Keywords

Ebola virusVirologyImmunogenicityVirus-like particleBiologyVP40NucleoproteinEbola vaccineImmune systemMarburg virusVirusRecombinant DNAImmunologyGene

Affiliated Institutions

Related Publications

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2018–19 Influenza Season

Lisa A. Grohskopf , Leslie Z. Sokolow , Karen R. Broder +3 more

This report updates the 2017-18 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States ...

2018 MMWR Recommendations and Reports 1648 citations

Antigenic and Immunogenic Characterization of Recombinant Baculovirus-Expressed Severe Acute Respiratory Syndrome Coronavirus Spike Protein: Implication for Vaccine Design

Yuxian He , Jingjing Li , Susanne Heck +2 more

ABSTRACT The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates the receptor interaction and immune recognition and is considered a majo...

2006 Journal of Virology 135 citations

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

Lisa Oestereich , Anja Lüdtke , Stephanie Wurr +3 more

Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatmen...

2014 Antiviral Research 483 citations

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

Meagan Bolles , Meagan E. Deming , Kristin A. Long +8 more

ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) is an important emerging virus that is highly pathogenic in aged populations and is maintained with great diver...

2011 Journal of Virology 500 citations

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

Mimi Guebre‐Xabier , Nita Patel , Jing-Hui Tian +10 more

There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective effi...

2020 Vaccine 238 citations

Publication Info

Year: 2007
Type: article
Volume: 196
Issue: s2
Pages: S421-S429
Citations: 82
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Filovirus‐Like Particles Produced in Insect Cells: Immunogenicity and Protection in Rodents

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Kelly L. Warfield, 
                                
                                    Nichole A. Posten, 
                                
                                    Dana L. Swenson
                                
                                et al.
                            
                            (2007). 
                            Filovirus‐Like Particles Produced in Insect Cells: Immunogenicity and Protection in Rodents. 
                            The Journal of Infectious Diseases
                            , 196
                            (s2)
                            , S421-S429.
                            https://doi.org/10.1086/520612
                        

Identifiers

DOI: 10.1086/520612