Ferroptosis: past, present and future

Keywords

GPX4Programmed cell deathLipid peroxidationReactive oxygen speciesBiologyOxidative stressCell biologyGlutathione peroxidaseApoptosisCatalaseBiochemistry

Affiliated Institutions

Related Publications

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang , Brent R. Stockwell , Marcus Conrad

The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-depe...

2021 Nature Reviews Molecular Cell Biology 6117 citations

Ferroptosis: molecular mechanisms and health implications

Daolin Tang , Xin Chen , Rui Kang +1 more

2020 Cell Research 3511 citations

Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils

Nikolai A. Maianski , Dirk Roos , Taco W. Kuijpers

Tumor necrosis factor α (TNF-α) is a cytokine with multiple roles in the immune system, including the induction and potentiation of cellular functions in neutrophils (PMNs). TNF...

2003 Blood 123 citations

Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

Bengt Fadeel , Anders Åhlin , Jan‐Inge Henter +2 more

Abstract Human neutrophils have a short half-life and are believed to die by apoptosis or programmed cell death both in vivo and in vitro. We found that caspases are activated i...

1998 Blood 342 citations

Free Radicals in the Physiological Control of Cell Function

Wulf Dröge

At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate...

2002 Physiological Reviews 9689 citations

Publication Info

Year: 2020
Type: review
Volume: 11
Issue: 2
Pages: 88-88
Citations: 3671
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Ferroptosis: past, present and future

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3671

OpenAlex

Cite This

APA Style

                            
                                
                                    Jie Li, 
                                
                                    Feng Cao, 
                                
                                    He-liang Yin
                                
                                et al.
                            
                            (2020). 
                            Ferroptosis: past, present and future. 
                            Cell Death and Disease
                            , 11
                            (2)
                            , 88-88.
                            https://doi.org/10.1038/s41419-020-2298-2
                        

Identifiers

DOI: 10.1038/s41419-020-2298-2