Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors

2018 JAMA Oncology 2,385 citations

Abstract

In the largest evaluation of fatal ICI-associated toxic effects published to date to our knowledge, we observed early onset of death with varied causes and frequencies depending on therapeutic regimen. Clinicians across disciplines should be aware of these uncommon lethal complications.

Keywords

MedicineIpilimumabDurvalumabNivolumabPembrolizumabAtezolizumabTremelimumabAvelumabPharmacovigilancePneumonitisInternal medicineMyocarditisAdverse effectImmunologyOncologyCancerImmunotherapy

MeSH Terms

Antineoplastic AgentsImmunologicalDatabasesFactualDrug-Related Side Effects and Adverse ReactionsGenescdcHumansImmunologic FactorsImmunotherapyIncidenceNeoplasmsPharmacovigilanceProtein Kinase InhibitorsRetrospective Studies

Affiliated Institutions

Related Publications

Publication Info

Year
2018
Type
review
Volume
4
Issue
12
Pages
1721-1721
Citations
2385
Access
Closed

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

2385
OpenAlex
97
Influential
2184
CrossRef

Cite This

Daniel Wang, Joe‐Elie Salem, Justine V. Cohen et al. (2018). Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors. JAMA Oncology , 4 (12) , 1721-1721. https://doi.org/10.1001/jamaoncol.2018.3923

Identifiers

DOI
10.1001/jamaoncol.2018.3923
PMID
30242316
PMCID
PMC6440712

Data Quality

Data completeness: 86%