Familial adult motor neuron disease: amyotrophic lateralsclerosis

Abstract

We analyzed the medical records of 103 patients with familial adult motor neuron disease (MND). In the 72 families, 329 members were known to be affected. Observations were compared with the sporadic and Mariana forms of MND. Clinical and laboratory examinations of all three forms were similar in clinical course and findings, but there were minor variations in age at onset, sex ratio, survival, and the frequency with which onset occurred in the lower extremities. Recognition of the familial form still depends on diagnosis of the disease in more than one member of a family.

Keywords

Amyotrophic lateral sclerosisMotor neuronDiseaseMedicineAge of onsetPediatricsDegenerative diseaseInternal medicine

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Publication Info

Year: 1986
Type: article
Volume: 36
Issue: 4
Pages: 511-517
Citations: 399
Access: Closed

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APA Style

                            
                                
                                    Daan Mulder, 
                                
                                    L. T. Kurland, 
                                
                                    Kenneth P. Offord
                                
                                et al.
                            
                            (1986). 
                            Familial adult motor neuron disease: amyotrophic lateralsclerosis. 
                            Neurology
                            , 36
                            (4)
                            , 511-517.
                            https://doi.org/10.1212/wnl.36.4.511
                        

Identifiers

DOI: 10.1212/wnl.36.4.511