Abstract

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH 2 T cell clones that inhibits synthesis of cytokines by mouse TH 1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.

Keywords

VirusBiologyOpen reading frameVirologyInterleukin 15Recombinant DNAImmune systemCytokineMolecular biologyInterleukinPeptide sequenceGeneGenetics

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Publication Info

Year
1990
Type
article
Volume
250
Issue
4982
Pages
830-832
Citations
535
Access
Closed

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Di‐Hwei Hsu, René de Waal Malefyt, David Fiorentino et al. (1990). Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1. Science , 250 (4982) , 830-832. https://doi.org/10.1126/science.2173142

Identifiers

DOI
10.1126/science.2173142