Abstract

Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.

Keywords

OncogeneBiologyMalignant transformationSarcomaCancer researchHaematopoiesisProto-OncogenesIn vivoIn vitroCancerPathologyMedicineCell biologyStem cellCell cycleGenetics

Affiliated Institutions

Related Publications

Publication Info

Year
1984
Type
article
Volume
224
Issue
4646
Pages
256-262
Citations
833
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

833
OpenAlex

Cite This

Dennis J. Slamon, Jean B. deKernion, Inder M. Verma et al. (1984). Expression of Cellular Oncogenes in Human Malignancies. Science , 224 (4646) , 256-262. https://doi.org/10.1126/science.6538699

Identifiers

DOI
10.1126/science.6538699