Abstract
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.
Keywords
Epithelial–mesenchymal transitionFibrosisMesenchymal stem cellContext (archaeology)Cancer researchBiologyMechanism (biology)DiseasePathologyCell biologyMedicineTransition (genetics)GeneticsGene
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Publication Info
- Year
- 2003
- Type
- article
- Volume
- 112
- Issue
- 12
- Pages
- 1776-1784
- Citations
- 2174
- Access
- Closed
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Cite This
Raghu Kalluri,
Eric G. Neilson
(2003).
Epithelial-mesenchymal transition and its implications for fibrosis.
Journal of Clinical Investigation
, 112
(12)
, 1776-1784.
https://doi.org/10.1172/jci200320530
Identifiers
- DOI
- 10.1172/jci200320530