Abstract In rabbits, anesthetized with urethane‐chloralose. the activation of the granule cells of the dentate area by perforant path fibres from the entorhinal area was studied by intracellular and extracellular recording. Intracellular recording showed that the perforant path produced a large EPSP in the granule cells, followed after 2–4 msec by a large IPSP, lasting some 100 msec. Field potential studies indicated that the synapses responsible for the EPSP were located on the middle third of the dendritic tree, whereas the IPSP was generated by synapses at, or very close to, the cell bodies. The most likely explanation is that the inhibition is mediated by a recurrent inhibitory pathway, in which the collaterals of the granule cell axons excite the basket cells These are inhibitory in nature and send their axons to terminate upon the somata of many granule cells. The inhibition of the granule cells produced by the perforant path is resistant to strychnine in doses up to 0.6 mg/kg. The efficiency of the perforant path excitatory synapses was greatly increased by raising the rate of stimulation from 1 to 10 a second.
1. The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrod...
The hippocampus is an area of the brain involved in learning and memory. It contains parallel excitatory pathways referred to as the trisynaptic pathway (which carries informati...
Abstract A detailed study of the origin and termination of the so‐called perforant path of the hippocampal region has been made in the rat. This tract connects the entorhinal ar...
Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the regenerative capacity o...
Abstract Two neuronal calcium‐binding proteins, calbindin‐D 28k (CaBP) and parvalbumin (PV), were localized in the normal rat hippocampus by using immunocytochemical methods to ...
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