Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year Follow-up of the Qidong Hepatitis B Intervention Study: A Cluster Randomized Controlled Trial

Chunfeng Qu; Taoyang Chen; Chunsun Fan; Qimin Zhan; Yuting Wang; Jianhua Lu; Lingling Lu; Zhengping Ni; Fei Huang; Hongyu Yao; Jian Zhu; Jian Fan; Yuan‐Rong Zhu; Zhiyuan Wu; Guoting Liu; Wenhong Gao; Mengya Zang; Dongmei Wang; Min Dai; Chu Chieh Hsia; Yawei Zhang; Zongtang Sun

doi:10.1371/journal.pmed.1001774

Abstract

Neonatal HBV vaccination was found to significantly decrease HBsAg seroprevalence in childhood through young adulthood and subsequently reduce the risk of PLC and other liver diseases in young adults in rural China. The findings underscore the importance of neonatal HBV vaccination. Our results also suggest that an adolescence booster should be considered in individuals born to HBsAg-positive mothers and who have completed the HBV neonatal vaccination series. Please see later in the article for the Editors' Summary.

Keywords

MedicineVaccinationHepatitis BPopulationHBsAgHepatitis B virusRandomized controlled trialLiver cancerFulminant hepatitisInternal medicineHepatitis B vaccinePediatricsImmunologyHepatitisCancerEnvironmental healthVirus

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Publication Info

Year: 2014
Type: article
Volume: 11
Issue: 12
Pages: e1001774-e1001774
Citations: 148
Access: Closed

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APA Style

                            
                                
                                    Chunfeng Qu, 
                                
                                    Taoyang Chen, 
                                
                                    Chunsun Fan
                                
                                et al.
                            
                            (2014). 
                            Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year Follow-up of the Qidong Hepatitis B Intervention Study: A Cluster Randomized Controlled Trial. 
                            PLoS Medicine
                            , 11
                            (12)
                            , e1001774-e1001774.
                            https://doi.org/10.1371/journal.pmed.1001774
                        

Identifiers

DOI: 10.1371/journal.pmed.1001774