Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

Abstract

Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic gastrointestinal stromal tumor. Inhibition of the KIT signal-transduction pathway is a promising treatment for advanced gastrointestinal stromal tumors, which resist conventional chemotherapy.

Keywords

MedicineImatinibImatinib mesylateTyrosine-kinase inhibitorTolerabilityInternal medicineGastroenterologySunitinibMyeloid leukemiaClinical trialTyrosine kinaseOncologyAdverse effectPharmacologyCancerReceptor

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Publication Info

Year: 2002
Type: article
Volume: 347
Issue: 7
Pages: 472-480
Citations: 4336
Access: Closed

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APA Style

                            
                                
                                    George D. Demetri, 
                                
                                    Margaret von Mehren, 
                                
                                    Charles D. Blanke
                                
                                et al.
                            
                            (2002). 
                            Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors. 
                            New England Journal of Medicine
                            , 347
                            (7)
                            , 472-480.
                            https://doi.org/10.1056/nejmoa020461
                        

Identifiers

DOI: 10.1056/nejmoa020461