Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Abstract

In patients with glucocorticoid-dependent severe asthma, dupilumab treatment reduced oral glucocorticoid use while decreasing the rate of severe exacerbations and increasing the FEV<sub>1</sub>. Transient eosinophilia was observed in approximately 1 in 7 dupilumab-treated patients. (Funded by Sanofi and Regeneron Pharmaceuticals; LIBERTY ASTHMA VENTURE ClinicalTrials.gov number, NCT02528214 .).

Keywords

DupilumabAsthmaGlucocorticoidMedicineRescue therapyDermatologyImmunologyInternal medicine

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Publication Info

Year: 2018
Type: article
Volume: 378
Issue: 26
Pages: 2475-2485
Citations: 1086
Access: Closed

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APA Style

                            
                                
                                    Klaus F. Rabe, 
                                
                                    Parameswaran Nair, 
                                
                                    Guy Brusselle
                                
                                et al.
                            
                            (2018). 
                            Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma. 
                            New England Journal of Medicine
                            , 378
                            (26)
                            , 2475-2485.
                            https://doi.org/10.1056/nejmoa1804093
                        

Identifiers

DOI: 10.1056/nejmoa1804093