Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

Keywords

RadioligandPositron emission tomographyPet imagingNeuroscienceTau pathologyNeuroimagingCognitive impairmentMedicineDiseaseAlzheimer's diseasePathologyPsychologyInternal medicineReceptor

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Year
2013
Type
article
Volume
34
Issue
2
Pages
457-468
Citations
642
Access
Closed

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David Chien, Shadfar Bahri, Anna Katrin Szardenings et al. (2013). Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807. Journal of Alzheimer s Disease , 34 (2) , 457-468. https://doi.org/10.3233/jad-122059

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DOI
10.3233/jad-122059