Abstract

We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

Keywords

ChemistryNitrilotriacetic acidIron oxide nanoparticlesNanoparticleMoleculeIron oxideCovalent bondMagnetic nanoparticlesNanostructureOxideBiocompatibilityNanotechnologyCombinatorial chemistryInorganic chemistryOrganic chemistryChelation

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Publication Info

Year
2004
Type
article
Volume
126
Issue
32
Pages
9938-9939
Citations
870
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Closed

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Chenjie Xu, Keming Xu, Hongwei Gu et al. (2004). Dopamine as A Robust Anchor to Immobilize Functional Molecules on the Iron Oxide Shell of Magnetic Nanoparticles. Journal of the American Chemical Society , 126 (32) , 9938-9939. https://doi.org/10.1021/ja0464802

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DOI
10.1021/ja0464802