Keywords
G2-M DNA damage checkpointBiologyCell cycle checkpointDNA repairCHEK1Cell biologyDNA replicationDNA damageEukaryotic DNA replicationDNAGeneticsComputational biologyCell cycleGene
Affiliated Institutions
Related Publications
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellul...
Genomic instability and endoreduplication triggered by <i>RAD17</i> deletion
Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage a...
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair. Chemical inhibitors of the G(2) phase DNA damage check...
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxicstress is only par...
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
DNA double-strand breaks originating from diverse causes in eukaryotic cells are accompanied by the formation of phosphorylated H2AX (gammaH2AX) foci. Here we show that gammaH2A...
Publication Info
- Year
- 2002
- Type
- review
- Volume
- 1
- Issue
- 12
- Pages
- 983-994
- Citations
- 134
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
134
OpenAlex
Cite This
Antony M. Carr
(2002).
DNA structure dependent checkpoints as regulators of DNA repair.
DNA repair
, 1
(12)
, 983-994.
https://doi.org/10.1016/s1568-7864(02)00165-9
Identifiers
- DOI
- 10.1016/s1568-7864(02)00165-9