DNA Markers for Nervous System Diseases

Abstract

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.

Keywords

BiologyGeneticsGeneDNA sequencingGenetic markerDNARecombinant DNANervous systemCloning (programming)Computational biologyNeuroscience

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Publication Info

Year: 1984
Type: article
Volume: 225
Issue: 4668
Pages: 1320-1326
Citations: 130
Access: Closed

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APA Style

                            
                                
                                    Gusella James F, 
                                
                                    Rudolph E. Tanzi, 
                                
                                    Mary Anne Anderson
                                
                                et al.
                            
                            (1984). 
                            DNA Markers for Nervous System Diseases. 
                            Science
                            , 225
                            (4668)
                            , 1320-1326.
                            https://doi.org/10.1126/science.6089346
                        

Identifiers

DOI: 10.1126/science.6089346