Abstract
Pittard, James (School of Microbiology, University of Melbourne, Victoria, Australia), and B. J. Wallace . Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli . J. Bacteriol. 91: 1494–1508. 1966.—A number of mutant strains of Escherichia coli K-12, which are blocked in the biosynthesis of the aromatic amino acids, were examined biochemically to determine their particular enzymatic deficiencies. The mutations carried by these strains were mapped by use of the methods of conjugation and transduction. Structural genes for five of the enzymes of the common pathway leading to chorismate and for the two enzymes converting chorismate to phenylpyruvate and p -hydroxyphenylpyruvate, respectively, were identified. Unlike the genes of the tryptophan operon most of these genes are distributed over widely separated regions of the chromosome.
Keywords
Escherichia coliOperonBiologyGeneBiosynthesisAromatic amino acidsMutantEnzymeBiochemistrytrp operonGeneticsTryptophanFunction (biology)EscherichiaShikimate pathwayAmino acid
Affiliated Institutions
Related Publications
Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism
E.A. SMITH AND G.T. MACFARLANE. 1996. Concentrations of phenolic compounds in human gut contents were more than fourfold higher in the distal colon (6.2 mmol kg ‐1 ) compared to...
Bile salt biotransformations by human intestinal bacteria
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may contribute to the pathog...
The Complete Genome Sequence of <i>Escherichia coli</i> K-12
The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five othe...
Excess information at bacteriophage T7 genomic promoters detected by a random cloning technique
In our previous analysis of the information at binding sites on nucleic acids, we found that most of the sites examined contain the amount of information expected from their fre...
VIP21/caveolin is a cholesterol-binding protein.
VIP21/caveolin is localized to both caveolae and apical transport vesicles and presumably cycles between the cell surface and the Golgi complex. We have studied the lipid intera...
Publication Info
- Year
- 1966
- Type
- article
- Volume
- 91
- Issue
- 4
- Pages
- 1494-1508
- Citations
- 215
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
215
OpenAlex
Cite This
J Pittard,
Brian Wallace
(1966).
Distribution and Function of Genes Concerned with Aromatic Biosynthesis in <i>Escherichia coli</i>.
Journal of Bacteriology
, 91
(4)
, 1494-1508.
https://doi.org/10.1128/jb.91.4.1494-1508.1966
Identifiers
- DOI
- 10.1128/jb.91.4.1494-1508.1966