Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Denis Arsenijevic; Hiroki Onuma; Claire Pecqueur; Serge Raimbault; Brian S. Manning; Bruno Miroux; Elodie Couplan; Marie‐Clotilde Alves‐Guerra; Marc Goubern; Richard S. Surwit; Frédéric Bouillaud; Denis Richard; Sheila Collins; Daniel Ricquier

doi:10.1038/82565

Keywords

BiologyReactive oxygen speciesImmunityInflammationWild typeGeneMitochondrial ROSSpleenMacrophageMolecular biologyImmunologyCell biologyIn vitroImmune systemGeneticsMutant

Affiliated Institutions

Related Publications

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

Antonio Vidal‐Puig , Danica Grujić , Chenyu Zhang +9 more

Uncoupling protein 3 (UCP3) is a member of the mitochondrial anion carrier superfamily. Based upon its high homology with UCP1 and its restricted tissue distribution to skeletal...

2000 Journal of Biological Chemistry 675 citations

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

Ruzhou Zhao , Shuai Jiang , Lin Zhang +1 more

The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron tran...

2019 International Journal of Molecular Me... 1326 citations

Mechanisms of ROS Regulation of Plant Development and Stress Responses

Honglin Huang , Farhan Ullah , Dao‐Xiu Zhou +2 more

Plants are subjected to various environmental stresses throughout their life cycle. Reactive oxygen species (ROS) play important roles in maintaining normal plant growth, and im...

2019 Frontiers in Plant Science 1345 citations

Mitochondrial disease in mouse results in increased oxidative stress

Luke Esposito , Simon Melov , Alexander Panov +2 more

It has been hypothesized that a major factor in the progression of mitochondrial disease resulting from defects in oxidative phosphorylation (OXPHOS) is the stimulation of the m...

1999 Proceedings of the National Academy o... 629 citations

The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

Till Acker , Joachim Fandrey , H. Acker

Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (E...

2006 Cardiovascular Research 110 citations

Publication Info

Year: 2000
Type: article
Volume: 26
Issue: 4
Pages: 435-439
Citations: 1070
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1070

OpenAlex

Cite This

APA Style

                            
                                
                                    Denis Arsenijevic, 
                                
                                    Hiroki Onuma, 
                                
                                    Claire Pecqueur
                                
                                et al.
                            
                            (2000). 
                            Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
                            Nature Genetics
                            , 26
                            (4)
                            , 435-439.
                            https://doi.org/10.1038/82565
                        

Identifiers

DOI: 10.1038/82565