Abstract
Advances in molecular profiling of metastatic CRC facilitate the ability to direct treatments to the biologic features of the tumor for specific patient subsets. Although cures remain uncommon, more patients can anticipate extended survival. Genomic profiling allows treatment selection so that more patients derive benefit and fewer are exposed to toxicity from ineffective therapies.
Keywords
MedicineKRASNeuroblastoma RAS viral oncogene homologPanitumumabColorectal cancerCetuximabOncologyInternal medicineTargeted therapyChemotherapyCancer
MeSH Terms
Antineoplastic AgentsColorectal NeoplasmsFemaleGenetic ProfileHumansMaintenance ChemotherapyMaleMolecular Diagnostic TechniquesPrognosisSurvival Rate
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Publication Info
- Year
- 2021
- Type
- review
- Volume
- 325
- Issue
- 7
- Pages
- 669-669
- Citations
- 2261
- Access
- Closed
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Cite This
Leah H. Biller,
Deborah Schrag
(2021).
Diagnosis and Treatment of Metastatic Colorectal Cancer.
JAMA
, 325
(7)
, 669-669.
https://doi.org/10.1001/jama.2021.0106
Identifiers
- DOI
- 10.1001/jama.2021.0106
- PMID
- 33591350