Design of the liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER) trial

Abstract

LEADER commenced in September 2010, and enrollment concluded in April 2012. There were 9,340 patients enrolled at 410 sites in 32 countries. The mean age of patients was 64.3 ± 7.2 years, 64.3% were men, and mean body mass index was 32.5 ± 6.3 kg/m2. There were 7,592 (81.3%) patients with prior CVD and 1,748 (18.7%) who were high risk but without prior CVD. It is expected that LEADER will provide conclusive data regarding the cardiovascular safety of liraglutide relative to the current standard of usual care for a global population of patients with T2DM.

Keywords

MedicineLiraglutideMyocardial infarctionDiabetes mellitusInternal medicineStroke (engine)PlaceboClinical endpointType 2 diabetesBody mass indexRandomized controlled trialHeart failureEndocrinology

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Publication Info

Year: 2013
Type: article
Volume: 166
Issue: 5
Pages: 823-830.e5
Citations: 238
Access: Closed

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APA Style

                            
                                
                                    Steven P. Marso, 
                                
                                    Neil R Poulter, 
                                
                                    Steven E. Nissen
                                
                                et al.
                            
                            (2013). 
                            Design of the liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER) trial. 
                            American Heart Journal
                            , 166
                            (5)
                            , 823-830.e5.
                            https://doi.org/10.1016/j.ahj.2013.07.012
                        

Identifiers

DOI: 10.1016/j.ahj.2013.07.012