Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Keywords

BiologyCryptStem cellEpitheliumEmbryonic stem cellIntestinal epitheliumCell biologyCateninBeta-cateninMolecular biologyGeneWnt signaling pathwayCancer researchGeneticsEndocrinology

Affiliated Institutions

University Medical Center Utrecht NL

Related Publications

Morphogenesis of the Polarized Epithelial Cell Phenotype

Enrique Rodríguez-Boulan , W. James Nelson

Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelia...

1989 Science 1082 citations

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

Thomas Brabletz , Andreas Jung , Simone Reu +5 more

Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor c...

2001 Proceedings of the National Academy o... 1026 citations

β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

Alan Jian Zhu , Fiona M. Watt

ABSTRACT We found that cultured human keratinocytes with high proliferative potential, the putative epidermal stem cells, expressed a higher level of noncadherin-associated β- c...

1999 Development 240 citations

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

Ethan A. Carver , Rulang Jiang , Yu Lan +2 more

Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the format...

2001 Molecular and Cellular Biology 615 citations

The Snail genes as inducers of cell movement and survival: implications in development and cancer

Alejandro Barrallo‐Gimeno , M. Ángela Nieto

The functions of the Snail family of zinc-finger transcription factors are essential during embryonic development. One of their best-known functions is to induce epithelial to m...

2005 Development 1369 citations

Publication Info

Year: 1998
Type: article
Volume: 19
Issue: 4
Pages: 379-383
Citations: 1560
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1560

OpenAlex

Cite This

APA Style

                            
                                
                                    Vladimír Kořínek, 
                                
                                    Nick Barker, 
                                
                                    Petra Moerer
                                
                                et al.
                            
                            (1998). 
                            Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. 
                            Nature Genetics
                            , 19
                            (4)
                            , 379-383.
                            https://doi.org/10.1038/1270
                        

Identifiers

DOI: 10.1038/1270