Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives

Léa Bientz; Raoudha Grami; Marin Lahouati; Melissande Hertzmann; André Augusto Franco Marques; Alexis Groppi; Véronique Dubois

doi:10.1186/s12866-025-04517-z

Abstract

Ceftolozane/tazobactam resistance development was associated mainly with chromosomal mutations in the ampC gene but also with mutations in its regulatory genes. Knowledge about these mutations and gene polymorphisms is essential for interpreting resistance phenotypes from genomic data.

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Year: 2025
Type: article
Citations: 0
Access: Closed

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APA Style

                            
                                    Léa Bientz, 
                                
                                    Raoudha Grami, 
                                
                                    Marin Lahouati
                                
                                et al.
                            
                            (2025). 
                            Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives. 
                            BMC Microbiology
                            
                            .
                            https://doi.org/10.1186/s12866-025-04517-z

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DOI: 10.1186/s12866-025-04517-z