Cyclic polyamides for recognition in the minor groove of DNA.

Jang‐Cheon Cho; Michelle E. Parks; Peter B. Dervan

doi:10.1073/pnas.92.22.10389

Abstract

Small molecules that specifically bind with high affinity to any designated DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to rationally alter the sequence specificity of minor groove-binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Crescent-shaped polyamides bind as antiparallel dimers with each polyamide making specific contacts with each strand on the floor of the minor groove. Cyclic polyamides have now been synthesized that bind designated DNA sequences at subnanomolar concentrations.

Keywords

Antiparallel (mathematics)Minor grooveDNAPolyamideGroove (engineering)Sequence (biology)BiochemistryChemistryStereochemistryPolymer chemistryMaterials science

Affiliated Institutions

California Institute of Technology US

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Publication Info

Year: 1995
Type: article
Volume: 92
Issue: 22
Pages: 10389-10392
Citations: 52
Access: Closed

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APA Style

                            
                                    Jang‐Cheon Cho, 
                                
                                    Michelle E. Parks, 
                                
                                    Peter B. Dervan
                                
                            (1995). 
                            Cyclic polyamides for recognition in the minor groove of DNA.. 
                            Proceedings of the National Academy of Sciences
                            , 92
                            (22)
                            , 10389-10392.
                            https://doi.org/10.1073/pnas.92.22.10389

Identifiers

DOI: 10.1073/pnas.92.22.10389