Abstract
We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
Keywords
CryoablationBlockadeTrampCancer researchCD8MedicineProstate cancerImmunotherapyAntigenCancerImmunologyImmune systemInternal medicineReceptor
Affiliated Institutions
Related Publications
Cancer immunotherapy using checkpoint blockade
The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses i...
The biologic importance of tumor‐infiltrating lymphocytes
Detailed pathologic analysis has delineated a close association between intratumoral CD 8 + cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the...
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we ...
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancer...
Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 but Also Interphotoreceptor Retinoid Binding Protein–Specific Th1 by Promoting Regulatory T Cells in Experimental Autoimmune Uveoretinitis
PURPOSE. Both Th17 and Th1 cells contribute to experimental autoimmune uveoretinitis (EAU). Interleukin-6 (IL-6) blockade inhibits Th17 differentiation in EAU and potently suppr...
Publication Info
- Year
- 2012
- Type
- article
- Volume
- 1
- Issue
- 4
- Pages
- 544-546
- Citations
- 33
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
33
OpenAlex
Cite This
Rebecca Waitz,
Marcella Fassò,
James P. Allison
(2012).
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.
OncoImmunology
, 1
(4)
, 544-546.
https://doi.org/10.4161/onci.19442
Identifiers
- DOI
- 10.4161/onci.19442