Abstract
The most progress has been made on SARS-CoV E, highlighting specific structural requirements for its functions in the CoV life cycle as well as mechanisms behind its pathogenesis. Data shows that E is involved in critical aspects of the viral life cycle and that CoVs lacking E make promising vaccine candidates. The high mortality rate of certain CoVs, along with their ease of transmission, underpins the need for more research into CoV molecular biology which can aid in the production of effective anti-coronaviral agents for both human CoVs and enzootic CoVs.
Keywords
BiologyEnzooticCoronavirusViral pathogenesisViral life cycleMiddle East respiratory syndrome coronavirusVirologyMiddle East respiratory syndromeViral envelopeComputational biologyCoronavirus disease 2019 (COVID-19)VirusViral replicationDiseaseInfectious disease (medical specialty)Medicine
MeSH Terms
AnimalsCoronavirusCoronavirus InfectionsHumansSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory SyndromeViral Envelope ProteinsZoonoses
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Publication Info
- Year
- 2019
- Type
- review
- Volume
- 16
- Issue
- 1
- Pages
- 69-69
- Citations
- 2144
- Access
- Closed
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Cite This
Dewald Schoeman,
Burtram C. Fielding
(2019).
Coronavirus envelope protein: current knowledge.
Virology Journal
, 16
(1)
, 69-69.
https://doi.org/10.1186/s12985-019-1182-0
Identifiers
- DOI
- 10.1186/s12985-019-1182-0
- PMID
- 31133031
- PMCID
- PMC6537279