Confirmatory interleukin-1 receptor antagonist trial in severe sepsis

Abstract

A 72-hr, continuous intravenous infusion of rhIL-1ra failed to demonstrate a statistically significant reduction in mortality when compared with standard therapy in this multicenter clinical trial. If rhIL-1ra treatment has any therapeutic activity in severe sepsis, the incremental benefits are small and will be difficult to demonstrate in a patient population as defined by this clinical trial.

Keywords

MedicinePlaceboSeptic shockInterim analysisSepsisMulticenter trialShock (circulatory)Internal medicineRandomized controlled trialAnesthesiaMortality rateMulticenter study

Affiliated Institutions

Cornell University US

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Publication Info

Year: 1997
Type: article
Volume: 25
Issue: 7
Pages: 1115-1124
Citations: 850
Access: Closed

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APA Style

                            
                                
                                    Steven M. Opal, 
                                
                                    Charles J. Fisher, 
                                
                                    Jean-François Dhainaut
                                
                                et al.
                            
                            (1997). 
                            Confirmatory interleukin-1 receptor antagonist trial in severe sepsis. 
                            Critical Care Medicine
                            , 25
                            (7)
                            , 1115-1124.
                            https://doi.org/10.1097/00003246-199707000-00010
                        

Identifiers

DOI: 10.1097/00003246-199707000-00010