Comparison of treatment effects between animal experiments and clinical trials: systematic review

Pablo Perel; Ian Roberts; Emily S. Sena; Philippa C. R. Wheble; Catherine L Briscoe; Peter Sandercock; Malcolm Macleod; Luciano Mignini; Pradeep Jayaram; Khalid S. Khan

doi:10.1136/bmj.39048.407928.be

Abstract

Discordance between animal and human studies may be due to bias or to the failure of animal models to mimic clinical disease adequately.

Keywords

MedicineConfidence intervalOdds ratioClinical trialStroke (engine)Randomized controlled trialNumber needed to harmMeta-analysisThrombolysisRespiratory distressFibrinolytic agentRelative riskInternal medicineIntensive care medicineSurgeryNumber needed to treatMyocardial infarctionTissue plasminogen activator

MeSH Terms

Animal ExperimentationAnimalsBiasClinical Trials as TopicHumansModelsAnimalResearch DesignTreatment Outcome

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Publication Info

Year: 2006
Type: review
Volume: 334
Issue: 7586
Pages: 197-197
Citations: 785
Access: Closed

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APA Style

                            
                                
                                    Pablo Perel, 
                                
                                    Ian Roberts, 
                                
                                    Emily S. Sena
                                
                                et al.
                            
                            (2006). 
                            Comparison of treatment effects between animal experiments and clinical trials: systematic review. 
                            BMJ
                            , 334
                            (7586)
                            , 197-197.
                            https://doi.org/10.1136/bmj.39048.407928.be
                        

Identifiers

DOI: 10.1136/bmj.39048.407928.be
PMID: 17175568
PMCID: PMC1781970

Data Quality

Data completeness: 86%